Middle-aged, sexually repressed Sylvia Stickles is the subject of this John Water's film, set in North Baltimore. She refuses to have sex with her husband, Vaughn Stickles, and keeps her overly-endowed daughter, Caprice, locked in her room, while she serves home detention for moral depravity charges. Sylvia, together with her mother Big Ethel, lead a group calling themselves "neuters" that promotes decency on Harford Road. When Sylvia is accidentally hit on the head by a lawnmower hanging out of a passing pick-up truck, however, her sexual behavior is changed completely from prude to prostitute. She meets the sex addicted sexual healer Ray Ray Perkins, becoming his twelfth apostle of sex in a journey of pleasure and orgasm.